Mold & Brain Disorders

advanced, research-based alternative and conventional medical treatments

What Brain Disorders Are Caused By Mold Toxicity?

Every neurodegenerative disease, from autism and multiple sclerosis to Alzheimer’s and ALS, has studies that reveal evidence of fungi in the brain.

Mold toxins destroy the myelin sheath and axons through lipid peroxidation and oxidative stress. As a result, causing neurodegeneration, kills olfactory neurons, and damages the membranes and mitochondrial of cells.

Mold toxins are lipophilic, fatty in molecular structure, and fat-soluble. The cell membrane of every cell in our body consists of a lipophilic structure. Therefore, these lipophilic toxins can travel uninhibited throughout the body.

These fatty toxins move throughout our bloodstream, easily cross and destroy our blood-brain barrier, and then accumulate in our fattiest tissue, our neurological system; thus, the term Neurotoxicity.

Our fattiest organ is our Brain which consists of 60 percent fatty content. The fattiest tissue in our body is the myelin sheath on the Brain Neurons and peripheral nerves. It consists of 80 percent fatty content, 25 percent of which is cholesterol; another reason cholesterol levels below 180 are detrimental to our Brain and peripheral nervous system!

When lipophilic mold toxins saturate the myelin sheath, they displace healthy fatty acids like DHA and EPA from fatty acid chains, causing fatty acid oxidation and lipid peroxidation.

Subsequent inflammation of the myelin sheath causes “burning” neuropathic pain. Females in particular, get burning pain in their feet and legs.

Inflammation of the myelin sheath disrupts the electromagnetic field surrounding neurons which causes a subsequent reduction of the electrical signal.

When mycotoxins affect the brain.

People afflicted with toxic mold syndrome often have numerous systemic symptoms, including cognitive-related problems such as:

  • Headaches
  • Forgetfulness
  • Impaired memory
  • Inability to recall words
  • Vertigo and dizziness
  • Poor concentration and more.

Mycotoxins can impact mental health as well, contributing to anxiety, depression, mood swings, or behavioral changes that compound other neurological symptoms.

How Does Sponaugle Wellness treat mold-related brain disorders?

At Sponaugle Wellness Institute, we have successfully treated thousands of patients who suffered from these mood disorders because psychiatrists failed to diagnose the underlying cause of their psychological symptoms. For this reason, they did not respond to traditional psychiatric treatment.

Historically, Psychiatrists and other mental health professionals have assumed that most mood disorders are derived from the patient’s inability to cope with life’s stressors.

However, our clinical research at Sponaugle Wellness Institute has proven that the majority of patients struggling with Depression, Anxiety, and other mood disorders are unable to overcome their psychological symptomatology because the medical community has failed to diagnose the ever-increasing imbalance of brain chemistry in Americans.

Dr. Sponaugle has performed extensive clinical research regarding the Gut-Brain connection. He has written chapters for naturopathic physicians in which he elucidated the specific biochemical mechanisms by which Intestinal Overgrowth of Candida and pathogenic bacteria, such as Klebsiella, Proteus, and Enterobacteracia, cause mood-disrupting neurochemical imbalances.

Several recommendations are using the principles of integrative medicine to address mold toxicity, featuring a comprehensive program that focuses on eliminating mold from your environment (both home and work) as much as possible and measures to rid your system of these pathogens.

Using phospholipid therapy with IV phosphatidylcholine, IV alpha lipoic acid, and IV glutathione, as well as colon hydrotherapy, Dr. Sponaugle has helped thousands of patients release the lipophilic toxins from their cellular membranes and open their detox pathways to eliminate these harmful lipophilic toxins.

We also focus on neuroplasticity, stress reduction, quality sleep, and reducing the toxic load to help the liver, along with other efforts that consider a whole-system approach to helping you and your brain heal from the effects of mold exposure.

Mold Toxicity Causing Addiction, Leading to Depression, Anxiety, and Insomnia

At Sponaugle Wellness, Dr. Rick Sponaugle is proving that many patients develop alcoholism, OxyContin addiction, or Xanax addiction while attempting to self-medicate the following disorders caused by mold toxicity.


Dr. Sponaugle was recently informed by a top mold toxicity testing and diagnostic lab in Dallas that he is the top mold toxicity doctor in North America based on the results they see before and after treatment in patient samples.

The lab director, Dr. Hooper, was amazed that Dr. Sponaugle could diagnose mold toxicity with a 98 percent accuracy when other physicians using their testing averaged only 10 percent accuracy.

Dr. Sponaugle explained that he had correlated the brain scans of mold toxic patients with their brain chemistry patterns and mold toxin levels.

Similar patterns occur in patients suffering Benzene toxicity from the Gulf Oil Spill, which is less common than mold toxicity.

Dr. Sponaugle also explained that he had personally suffered mold toxicity, Trichothecene toxicity, which has enhanced his ability to recognize the mold toxicity patient.

Dr. Sponaugle further explained that he has been correlating brain neurotransmitter profiles with other indirect biomarkers of mold toxicity for years.

Among these biomarkers – are elevated immune markers [C3 A and C4 A ] and severe central hormonal suppression [pituitary hormones], including the following; Growth Hormone, MSH, ADH, TSH, ACTH, FSH, and LH.

Dr. Sponaugle says that many patients suffering from opiate addiction and Xanax addiction use drugs like Oxycontin and Xanax to “calm their anxious brains.”

These patients usually test positive for HLA-DRBQ genetics, which disallows the efficient removal of mold toxins from their bodies and brain.

Supposedly only 24 percent of Americans have HLA-DRBQ genetics. However, Dr. Sponaugle diagnoses this genetic disorder in 80 percent of his patients.

This genetic aberration is commonly found in patients of Irish, English, Scandinavian, German, and essentially northern European descent.

The immune system of patients with HLA-DRBQ genetics does not “tag” fatty toxins as abnormal or “foreign” to the body. Hence, these patients do not efficiently remove mold toxins from their brains and body.

Patients with HLA- DRBQ genetics remove mold toxins and other fatty toxins 468 percent less efficiently than other patients.

While the symptoms of mold toxicity are many, Dr. Sponaugle says specific symptoms are the driving force causation of drug addiction and or alcoholism. Initially, patients notice insomnia; then, they develop anxiety and insomnia.

As the brain accumulates higher levels of the mold toxins, Glutamate and PEA, two powerful electrifying brain chemicals, become elevated, producing excessive electrical activity in the brain, and worst-case scenarios, develop bipolar symptoms.

Patients self-medicate their brain’s upregulated “electrical voltage” with calming drugs like alcohol, Oxycontin-like medication, and benzodiazepines such as Xanax and Klonopin.

Dr. Sponaugle has treated many mold-toxic patients whose glutamate levels were so high that they exhibited bipolar symptoms and were sadly diagnosed bipolar by unknowing psychiatrists before coming to Dr. Sponaugle’s clinic.

University of South Florida psychiatrists misdiagnosed two young male patients as schizophrenic. The university psychiatrists were, of course, naive regarding mold toxicity.

Fortunately, Dr. Steven Stahl of Scripts University in San Diego wrote in his book on Bipolar and Schizophrenia about the possibility of excessive glutamate, not just excessive dopamine, being the cause of these disorders.

While Dr. Stahl did not make the connection with excessive accumulation of mold toxins as the cause of excessive glutamate production, it is a step in the right direction.

Dr. Sponaugle has found excessive glutamate levels in 9 of 10 patients previously diagnosed with bipolar. A condition felt by most to be derived from excessive dopamine production. Hence, the majority of the medications for Bipolar are dopamine blockers.

Dr. Sponaugle recently treated a paranoid 22-year-old male who University of Miami Psychiatrists had misdiagnosed as bipolar and schizophrenic.

When Michael failed to improve after six psychiatric admissions to the University of Miami Psych ward, his parents brought him to Florida Detox for Dr. Sponaugle’s evaluation.

Michael’s history consisted of living in a mold-infested apartment on Miami Beach for six months before he began to develop paranoia. He tested positive for high levels of the Trichothecene Black Mold toxin and Ochratoxin produced by Aspergillus Mold. Michael quickly responded to Dr. Sponaugle’s intravenous toxin removal program, his paranoia diminished after just one week, and after three weeks of treatment, his depression and anxiety were gone.*

Because mold toxins shut down hormonal production in the brain’s pituitary gland, patients suffer severe depression and chronic fatigue. Pure adrenaline [epinephrine] can not activate its receptors in the brain and body without cortisol; cortisol deficiency is common in mold-toxic patients. Dopamine can not activate the D2 dopamine receptor [happy receptor] in the brain’s pleasure center without adequate testosterone, and thyroid hormone, both of these hormones are deficient in mold-toxic patients.

Patients who suffer from mold toxicity utilize opiate pain pills for the opiate-induced dopamine hit in their dopamine-deprived pleasure center. This temporarily treats their depression. They also benefit from the relaxing “calcium channel blockade” effect of opiate pain pills, which brings quiescence to their “over-electrified” brain.

While mold-toxic patients experience severe depression and fatigue, they also feel like their brain is “hot-wired” or plugged into an electrical outlet.

Over time, as the mold toxicity worsens, patients begin to feel, from a physical perspective, as though they have a 25-pound cement block attached to each leg.

Their body feels weak, lethargic, and in slow motion, yet, their brain is over-electrified, anxious, irritable, and often exhibit rage.

Holistic Mold Toxicity Treatment Program

Learn about your treatment options, call a new patient care coordinator at 1-877-736-7180, or schedule a consultation with an integrative wellness physician to learn more about our integrative holistic approach to treating Lyme DiseaseMold Toxicity, & other complex diseases,

The clinic is located at 300 State St E #222, Oldsmar, FL 34677, near the Tampa International Airport (TPA). Environmental-friendly lodging and safe housing are available on-site at the clinic for out-of-state and international patients, as well as select on-site wellness amenities for weekly program patients and their loved ones.

Brain Disorders Caused by Mold Toxins

Neurological symptoms of mold eposure


In a healthy brain, the production of neurotransmitters that affect mood are self-regulated, naturally avoiding an imbalance that could lead to depression.

Paranoia & Anxiety

Paranoia can often be caused by high levels of toxic molds, such as the trichothecene black mold toxin or the Ocratoxin-producing Aspergilus Mold.

Irritability and Rage

Mold toxic patients often feel out of control in their own brain, describing the feeling by saying that it feels as if their brain is “hot wired.”

Parkinson’s Disease

A Parkinson’s disease diagnosis often results in a feeling of hopelessness.

Short-term Memory Loss

Do you ever walk into a room and think, “What did I come in here for?” Mold toxicity may be the reason.

Bipolar & Schizophrenic Tendencies

Glutamate is an amino acid found throughout every part of the body. In the nervous system, however, glutamate is used as a neurotransmitter.

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