Dr. Sponaugle Explains The
Chemistry of the Gut-Brain Connection

Suzanne Somers TOX-SICK Book Featured Interviews About Her Family’s Lyme Disease Treatment at Sponaugle Wellness Institute

The Road to Perfect Health by Brenda Watson

Brain & Nervous System
Balance Your Gut, Heal Your Body
of ADD-ADHD, Alzheimer’s Disease, Addiction**, Anxiety**, Depression**, Autism, Parkinson’s Disease

Featured Book Quotes from Dr. Sponaugle’s Chapters

“The gut houses the enteric nervous system, a part of the peripheral nervous system that is made up of 100 million neurons connecting the gut to the brain.”

“When the gut is in a state of dysbiosis, meaning that there is an imbalance in the ratio of good to bad bacteria, inflammation results. This inflammation destroys the cells lining the intestinal tract, leading to a condition known as increased intestinal permeability, or leaky gut. A leaky gut will allow undigested food particles and toxins (both microbial toxins and environmental toxins) to enter into the bloodstream. The immune system then responds to these particles and toxins as foreign invaders, which is the normal response of the immune system. This response triggers further immune dysregulation and inflammation, which can travel throughout the body manifesting in many different areas, including the brain.”

“Bringing the gut back into balance by recognizing the underlying contributing factors that create the imbalance in the first place, is the first step to building a healthy foundation upon which optimal brain function can be achieved.”

“Addiction is not a primary disease, but rather as a symptom, or a coping mechanism that patients use to bring their brain back into balance. Often patients use their addiction to anesthetize their emotional pain. Unknowingly, they strive to balance their brain chemistry which subsequently balances their brain’s electrical function.”


“Anxiety is essentially excess electrical current flowing through the brain. The human brain is both a chemical and an electrical organ. It consists of billions of electrical cells called neurons. Because various types of anxiety are derived from different brain regions, the symptoms of anxiety will vary.”

“Since 1980, anxiety and panic disorders have tripled in the U.S. At the same time, addiction has more than tripled. There is an obvious correlation.”

“The American Psychiatric Association has arbitrarily classified five main types of anxiety disorders based on patient symptoms, not causation.”

Generalized Anxiety Disorder (GAD)
Obessive- Compulsive Disorder (OCD)
Panic Disorder
Posy Traumatic Stress Disorder (PTSD)
Social Anxiety

What Causes It?

“Serotonin Deficiency Serotonin is a calming brain chemical. Serotonin deficiency is the most common cause of anxiety in Americans. Two chemical reactions are required for the production of serotonin. First, the amino acid tryptophan found in food is converted into 5-hydroxy tryptophan (5-HTP) in the small intestine. The second step occurs in the brain where 5-HTP is converted to serotonin.”

“Obviously, the treatment for anxiety disorders should be chosen based on causation. In the past, psychiatrists, psychologists and mental health counselors automatically assumed that most anxiety disorders were derived from the patient’s inability to cope with life’s stressors, or were sequence of sequelae negative emotional events.”

“We have determined that there are myriad neurobiological causes of anxiety that can be effectively treated in patients who have coexisting anxiety derived from emotional pain. In fact, when we optimize the patient’s brain function by correcting the neurobiological and biochemical causes of brain dysfunction, patients receive much more benefit then from counseling and cognitive behavioral therapy.”

Physical exercise should be a first line treatment for all anxiety disorders. Exercise releases multiple anti-anxiety chemicals including endorphins. Exercise pumps more blood into our brain, which increases the delivery of oxygen and nutrients needed to heal damaged brain cells. The increased cerebral blood flow derived from exercise also helps flush out or remove the many man-made brain toxins.

“Gastrointestinal dysbiosis with intestinal permeability, or leaky gut syndrome, is the most common undiagnosed causes of anxiety disorders in Americans. Unfortunately, undisclosed antibiotic levels in our city water and food supply destroy the normal flora (good bacteria) in unsuspecting Americans. Therefore, accurate diagnosis and treatment of toxic gut syndrome will greatly ameliorate or completely eliminate anxiety in a majority of patients.”

“Fixing a toxic gut will correct serotonin deficiency, taurine deficiency, magnesium deficiency, potassium deficiency, histamine excess and sometimes the more rare GABA deficiency coupled with glutamate excess.”

“The problem with the serotonergic medications (SSRIs) is that they do not assist the patient in making more serotonin. Their utility in the treatment of a serotonin deficient brain treats only the symptoms of serotonin deficiency. This is temporarily effective until the serotonin storage units are emptied.”

“Lyme disease and mold toxicity are the two most common causes of excessive brain toxicity in my patients. We have diagnosed more than 60 cases of Lyme disease out of 600 addicted patients we treated last year*. These patients had become addicted to OxyContin and Xanax attempting to treat the anxiety caused by the Lyme spirochete (bacterium).”

“Mold toxicity is endemic in the Southeastern United States and is under-diagnosed throughout America. Most American physicians are unaware that the toxins created by various indoor molds result in a tremendous elevation of the excitatory brain chemicals glutamate, phenylethylamine and histamine. Excessive activity of these stimulating brain chemicals causes severe anxiety, insomnia and even bipolar symptoms. Mold toxicity is a common cause of addiction as patients utilize Xanax-like drugs, OxyContin-like drugs or alcohol to quiet excessive electrical activity in their brains.”

“Treatment of anxiety derived from mold toxins includes oral and intravenous medications to remove mold toxins from the patient’s brain and body. Until all toxins can be removed, the excessive glutamate, PEA and histamine levels must be counteracted to decrease the brain’s electrical current to more normal levels. We utilize intravenous theanine and oral theanine to block glutamate activity at the NMDA receptor and N-acetylcysteine to facilitate increased production of glutathione, which accelerates toxin remove and glutamate metabalism.”

*Sponaugle Wellness Institute cannot guarantee individual patient outcomes.
Treatment results will vary from patient to patient.