Quercetin IV Therapy
Quercetin (flavonoid) is an antioxidant plant pigment found in numerous plants and foods, including red wine, onions, green tea, apples, and berries.
The more general category of polyphenols includes quercetin. It is particularly prevalent among flavonols, and unlike vitamins, when consumed, it is identified as a foreign chemical with kaempferol, myricetin, and isorhamnetin.
The most prevalent forms of quercetin, especially in the population of plants, are quercetin-3-O-glucoside or an aglycone.
The flavonoid in the diet that is most prevalent is quercetin. According to estimates, the average human takes between 10 and 100 mg of it every day through a variety of food sources.
Onions, apples, grapes, berries, broccoli, citrus fruits, cherries, green tea, coffee, red wine, and capers are among the foods that frequently contain quercetin.
It's also offered as a powdered and capsule nutritional supplement. People use this supplement for a variety of purposes, such as to increase resistance, reduce inflammation, reduce allergies, assist exercise performance, and preserve overall health.[3]
It's no secret that eating a diet full of vibrant fruits and veggies can help you prevent diseases like cancer, diabetes, and heart disease. But have you ever wondered how these plants manage to appear to have magical powers?
Bioflavonoids are one class of substance that plants have that is beneficial to health. These are naturally present in many fruits and vegetables and support your body's defense mechanisms against free radicals and other potentially harmful substances. A flavonoid known as quercetin is one of them that has been studied the most.
The plant pigment quercetin is a type of flavonoid which is a type of physiologically active molecule. Flavonoids are widely credited with many plants' vibrant colors and healing properties.
Flavonols, a kind of flavonoid that contains quercetin, cannot be made by the human body.
Many different plants, both edible and medicinal, contain this chemical. In addition, quercetin is available as a dietary supplement.
Quercetin strong antioxidant benefits have been proven in clinical investigations. Antioxidants are substances that protect your cells from the unstable and disease-causing free radicals that speed up the ageing process.[4]
What Are The Benefits of Quercetin IV Infusions?
Quercetin IV therapy has a potent potential to inhibit the growth of both bacteria and fungi, according to antimicrobial studies.
According to Yang (2020), the flavonoid quercetin inhibits the growth of specific bacteria by altering or breaking the bacterial cell wall; interfering with how bacteria generate and express proteins and enzymes; preventing bacteria from adhering to other cells; preventing bacteria from producing DNA and RNA.
While Quercetin's efficacy is significantly increased when paired with the antifungal drug amphotericin B, its effect on fungi is not as strong as it is on bacteria.
According to reports, quercetin possesses long-lasting anti-inflammatory properties. Numerous different cell types in both animals and people have been proven to be impacted by these potent anti-inflammatory properties.
Quercetin contains antioxidant and inflammatory attributes, which can be used in dealing with widespread allergy disorders. It has been demonstrated that quercetin may strengthen the immune system.
It can stop the body from releasing histamine and other compounds that cause allergies. Additionally, it has been demonstrated to stabilize the mast cell membrane, suggesting that it can assist in treating diseases linked to mast cells, such as rheumatoid arthritis, sinusitis, and asthma.
Some data suggests quercetin may be able to reduce blood pressure. Compared to a placebo, one study found quercetin to lower blood pressure significantly; however, additional research is required to determine the effects and the most effective dosage.
Quercetin may one day be used in addition to conventional antihypertensive drugs to provide additional benefits.
Animal studies have demonstrated that quercetin can help cure and stop the spread of cancer cells.
Cancers of the lungs, prostate, liver, breast, colon, skin, ovary, and cervical follicles are among them. Its capacity to assist in regulating cancer's routes to spread gives it anti-cancer effects. Additionally, it aids in promoting cancer cells' apoptosis (self-destruction).
Quercetin being an antioxidant, assists in reducing oxidative stress, which can harm your body's DNA, it helps to halt a process that might otherwise result in the growth of cancer cells.
According to research, the antioxidant properties of quercetin may help prevent degenerative brain diseases, including Alzheimer's and dementia. In one experiment, mice with Alzheimer's disease were injected with quercetin every two days for three months.
After the trial, the injections reversed multiple Alzheimer's disease signs, and the mice significantly improved on learning tests. In a different study, mice with early-stage middle-stage Alzheimer's disease showed enhanced brain function after eating a diet high in quercetin. On the other hand, animals with middle-late stage Alzheimer's showed little to no response to the diet.
Coffee is a well-liked beverage that may reduce your risk of developing Alzheimer's. Research indicates that the main coffee component responsible for its possible anti-inflammatory properties is quercetin, not caffeine.
Even though these results are encouraging, further human study is still required.
Three essential characteristics of quercetin flavonol distinguish it: immunomodulatory, anti-inflammatory, and antioxidant. Quercetin is a fantastic choice for treating conditions involving oxidative stress, inflammation, and the immune system. This combination of these three qualities provides a source that reflects the efficacy of a quercetin-based dietary supplement taken orally in preventing Covid-19 infection.
History of Quercetin in Medicine
Albert Szent-Györgyi discovered flavonoids in 1936 while researching ways to treat scurvy. He won the Nobel Prize in 1937 for his “discoveries in connection with the biological combustion processes with particular reference to vitamin C and the catalysis of fumaric acid.
Named after the oak genus Quercus, quercetin has been in use since 1857 and comes from the Latin word quercetin, which means "oak woodland." It is a polar auxin transport inhibitor that is found naturally. One of the most prevalent dietary flavonoids, quercetin, is consumed on average 25 to 50 mg daily.
The highest intake of quercetin was discovered in raw and canned capers, raw lovage leaves, dock-like sorrels, radish leaves, carob fiber, fresh dill weed, cilantro, raw yellow wax pepper, fennel leaves. The outermost rings and the area nearest to the root of red onions have higher levels of quercetin, with the latter region having the highest concentration. Â According to one study, tomatoes produced organically have 79% more quercetin than non-organically farmed fruit. Â Different types of honey from various plant sources contain quercetin.
The primary class D Beta-lactamase, OXA-48, was discovered in Turkey in 2001 and has spread widely worldwide.OXA-48 Beta-lactamase-mediated carbapenem resistance in Enterobacteriaceae is a significant danger to global health and has expanded quickly in many parts of the world. Antibiotic resistance can potentially be overcome by creating inhibitors.
Additionally, quercetin and piperacillin demonstrated antibacterial effectiveness in a mouse infection model. This research offers prospective lead compounds for creating Beta-lactamase inhibitors and for use in conjunction with Beta-lactams to treat pathogens that produce OXA-48. The alternatives for troublesome OXA-48 are, however, limited.
What Are The Mechanisms of Action for Quercetin IV Therapy?
Mechanisms of action of the pleiotropic effects of quercetin include enhanced glucose uptake by peripheral tissues, reduction of intestinal glucose absorption, and stimulation of insulin secretory and sensitizing actions.
Early research revealed quercetin has a low bioavailability. According to recent findings, quercetin has a lengthy half-life in the human body and has been found in plasma following food or supplement consumption.
Despite abundant in vitro and in vivo data demonstrating quercetin's antidiabetic potential, its effectiveness in diabetic humans has not yet been investigated.
The flavonol quercetin is one of the most often found and thoroughly researched flavonoids. Its potent anti-inflammatory and antioxidant properties are well known and are believed to help treat and prevent diseases like diabetes, cancer, neurodegenerative diseases, and cardiovascular diseases.
According to research, quercetin regulates whole-body glucose homeostasis by interacting with various molecular targets in the liver, pancreas, skeletal muscle, adipose tissue, and small intestine.
What Conditions Benefit from Quercetin IV Therapy?
Quercetin IV Therapy for Metabolic Syndrome
A flavonoid called quercetin, found in many fruits and vegetables, positively affects metabolic syndrome-related disorders. In this study, we employed a genetic model of metabolic syndrome to examine the metabolic and transcriptome responses to quercetin supplementation.
Male adult rats of the PD/Cub strain were fed either a high-sucrose diet (10 g quercetin/kg diet; PD-Q rats) or an HSD without quercetin (10 g HSD; control PD rats). The transcriptome profiles of the liver and retroperitoneal fat and morphometric and metabolic characteristics were evaluated.
In rats treated with quercetin, the relative weights of epididymal and retroperitoneal fat were dramatically reduced. Additionally, PD-Q rats had a lower fasting insulin level and a smaller area under the glycemic curve. Although there were no changes in total cholesterol levels, the PD-Q rats' liver and serum both had lower levels of triglycerides overall.
The liver's and the adipose tissue's transcriptome profiles supported the metabolic and morphometric results, showing a pattern compatible with modifications that make insulin more sensitive. The primary regulator nodes were Pparg, Adipoq, Nos2, and Mir378. Quercetin supplementation reduces metabolic syndrome-related disorders such as obesity, dyslipidemia, and glucose intolerance.
Quercetin IV Therapy for Type 2 Diabetes
The bioflavonoid quercetin, prevalent in foods like grapefruit, onions, and berries, has a wide range of therapeutic applications, primarily for treating Type 2 diabetes and associated consequences.
In cell line models, quercetin demonstrated effects comparable to metformin, a commonly prescribed antidiabetic medication. It also shows promise as a treatment for diabetes and associated pathophysiological consequences in in vivo studies.
The bioflavonoid quercetin, prevalent in foods like grapefruit, onions, and berries, has a wide range of therapeutic applications, primarily for treating Type 2 diabetes and associated consequences. In cell line models, quercetin demonstrated effects comparable to metformin, a commonly prescribed antidiabetic medication. It also shows promise as a treatment for diabetes and associated pathophysiological consequences in in vivo studies.
Quercetin can be synthesized on a large scale and used as a dietary supplement through a unique fermentation-based glycosylation technique using inexpensive substrates. The review focuses on the growing body of evidence supporting quercetin as a promising treatment option for type 2 diabetes and its pathophysiological consequences caused by oxidative stress.
The various targets of diabetes that quercetin affects, as well as the main signaling pathways it regulates, helping to reduce Type 2 diabetes complications as well as its symptoms. However, more research is required to increase quercetin's bioavailability and create a dose schedule.
Quercetin IV Therapy for Neurodegenerative Diseases
According to mounting evidence, most neurodegenerative disorders are caused by oxidative stress linked to aging. Polyphenols serve as antioxidants to lower the risk of neurodegenerative diseases.
A flavonoid called quercetin can be found in various plant foods frequently eaten as part of a regular diet. It demonstrates several biological traits linked to its antioxidant activity. This review evaluates quercetin's molecular makeup, dietary sources, and bioavailability.
Additionally, the key findings from in vitro research looking at the processes by which quercetin exerts its antioxidant activity are reported. The majority of these effects, meanwhile, have only been seen in vitro, and there aren't many clinical studies available.
Quercetin Administered Intravenously vs. Oral Supplementation
In 1975, six healthy human volunteers received a fixed dose of 100 mg of quercetin intravenously in an ethanol carrier without experiencing any adverse side effects. This investigation also showed that oral administration of the drug has very low oral bioavailability.
Another clinical experiment was conducted in 1996, around 20 years later. This trial was an escalation Phase I trial with an intravenous beginning dose of 60 mg/m2. This starting dose was determined based on the earlier volunteer study from 1975. Then, doses were raised until the maximum safe dose, 1400 mg/m2, was discovered and recommended for Phase II trials, administered at 3-week or weekly intervals.
According to tradition, Phase I studies should result in a recommendation of the dose to be investigated in Phase II studies. But in addition to establishing the suggested dosage, this study also showed that quercetin has anticancer properties.
One patient with cisplatin-resistant ovarian cancer, in particular, experienced a significant and long-lasting decline in serum CA 125 levels. Another hepatocellular cancer patient saw a decrease in a-fetoprotein from 460 to 40.
Although the results of this research clearly showed quercetin's safety against cancer, the scientists came to the following conclusion: "In conclusion, quercetin can be safely delivered by injection of a bolus-sized dosage. Evidence of anticancer efficacy was observed, and the plasma levels attained suppressed lymphocyte tyrosine kinase activity. However, no further testing was done following this study.
As Oral Supplementation, Hospitals administer quercetin as a medication in the form of capsules of 500mg for conditions other than cancer. Depending on the source, a vial of active bioflavonoid preparation comprises 500 mg (450 mg of polyvinylpyrrolidone and 50 mg of quercetin in 500 mg of powder form). The dosage is to be administered at reasonable times. Likewise, 500mg is used twice a day every month. The price ranges from 10 to 20 euros.
There is a lot of quercetin in food and nature. Between 5 and 40 milligrams are typically obtained through food each day. However, you can consume up to 500 milligrams daily if you consume many fruits and vegetables.
Molecular Structure of Quercetin IV
The molecular formula of IV Quercetin is C15H10O7, and its molecular weight is 338.27.
The IUPAC name of IV Quercetin is 2-(3,4-dihydroxy phenyl)-3,5,7-trihydroxychromen-4-one; dihydrate.
Quercetin IV Therapy FAQs
What is Quercetin IV Therapy?
Quercetin IV Therapy is an intravenous treatment that delivers the antioxidant quercetin directly into the bloodstream. Quercetin is a plant pigment (flavonoid) that is found in many fruits, vegetables, leaves, and grains. It has a variety of potential health benefits and is often used as a supplement for its anti-inflammatory and antihistamine properties.
What are the potential benefits of Quercetin IV Therapy?
The potential benefits of Quercetin IV Therapy include reducing inflammation, combatting allergies, supporting heart health, and improving exercise performance. By administering quercetin intravenously, it bypasses the digestive system, allowing for better absorption and more immediate effects compared to oral supplements.
Are there any side effects to Quercetin IV Therapy?
Quercetin is generally well-tolerated, but side effects can occur with any treatment. Potential side effects may include headache, upset stomach, or tingling of the arms and legs. As with any IV treatment, there's also a risk of infection, inflammation at the injection site, or an allergic reaction. Always discuss potential side effects and your personal health risks with a healthcare provider before beginning any new treatment.
Who should consider Quercetin IV Therapy?
Quercetin IV Therapy may be considered by individuals looking to boost their overall health, particularly those dealing with chronic conditions related to inflammation or immune response, such as allergies, cardiovascular disease, or chronic fatigue syndrome. However, it's important to consult with a healthcare provider to determine if this treatment is suitable for your specific needs.
How often can I get Quercetin IV Therapy?
The frequency of Quercetin IV Therapy depends on individual health conditions and needs. Some people may benefit from weekly sessions, while others might need it less frequently. Always follow the guidance of your healthcare provider, who will make recommendations based on your health history and treatment goals.