Treatment For Depression

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We successfully treat people with chronic depression who have failed to respond to traditional methods.

At Sponaugle Wellness we treat the underlying cause of depression, not just the symptoms. We’ve treated thousands of patients trapped in a never-ending spiral of depression. Many of these patients have been prescribed medications in an attempt to mask the symptoms instead of attacking the source of the depression.

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Are You Experiencing Depression Symptoms?

What Makes Depression Treatment At Sponaugle Wellness So Successful?

Holistic Treatment Backed by Science. In short, we use brain (PET) scans to determine diagnosis and best possible treatment options.

Our sophisticated depression research has correlated the various symptoms experienced by our depression patients with abnormal findings on their brain scans and abnormalities seen in their brain chemistry patterns. In addition, we have correlated their brain scans and brain chemistry patterns with over 500 various biomarkers for the following; gut toxicitymold toxicityindustrial toxicity, amino acid deficiencies, hormonal deficiencies, and brain infections like Lyme disease.

Our clinical research in depression patients has proven that neurotoxicity, the excessive accumulation of fatty toxins in the brain, can cause severe depression through down-regulation of electrical activity in the brain’s pleasure center. This is becoming a more common, but rarely diagnosed cause of depression, because each decade we are exposed to more environmental toxins.


Depression treatment offered by American psychiatrists remains at least 10 years behind the advanced brain research being produced on a daily basis by European and American neuroscientists. When psychiatrists are too complacent to perform research or spend time studying recent PET scan research, they remain ill-knowledgeable regarding multiple, newly known, biochemical and physiological causes of depression, most of which are readily treatable.

Unfortunately, most psychiatrists prefer reading about new psychiatric medications in drug company advertisements. Most of the “new drugs” are actually a new version of an old drug that no longer holds a patent. These drugs normally treat the psychological symptoms but rarely treat the underlying cause of depression.

Psychiatrists also demonstrate remarkable tunnel vision when they place their primary focus on using drugs to enhance the serotonin activity in the brain of their depressed patients. This modality of depression treatment was more effective 30 years ago when Americans suffered from less neurotoxicity and less malnutrition.

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Many Suffer Unknowingly From Melancholic Depression

Patients suffering from melancholic depression suffer experience many other changes in their personality in addition to depression. All of these symptoms are derived from a severely overactive deep limbic system, a walnut sized region located in our midbrain.


  • Moodiness, Irritability and Agitation

  • Constant Feelings of Hopelessness and Excessive Guilt

  • Chronic Low Self-Esteem Coupled with Low Motivation

  • Overwhelmed at Daily Tasks or Chores

  • Isolation and Social Anxiety

What Causes Melancholic Depression?

Research done by Dr. Sponaugle and the Sponaugle Wellness Team has found that Melancholic Depression is often caused by co-occurring disorders. These illnesses can be inherited or caused by our environment.


Destruction of the healthy bacteria in our intestine allows for excessive overgrowth of toxic Candida yeast and toxic bacteria.

This bacteria creates toxins that destroy the intestinal lining causing malnutrition and lack of amino acids that are essential for creating antidepressant brain chemicals like serotonin and dopamine. These toxins migrate from the gut to the brain causing neurotoxin-induced depression by disabling the production of healthy hormones needed to activate antidepressant brain chemicals.

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Mycotoxins from mold cause severe destruction of Brain tissue leaving patients with a dopamine deficiency and brain fog.

When mold toxins shut down norepinephrine production in the brain, it steals dopamine reserves to create the needed norepinephrine. This leaves patients with a relative dopamine deficiency.

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An inherited brain disorder causing a deficiency in dopamine, which causes happiness in the brain's pleasure center.

Called Reward Deficiency Syndrome (RDS), this depression is caused by an under-active reward center which controls a person’s ability to experience pleasure and happiness. Patients with RDS experience less activity in their brain’s pleasure center, even though they produce normal levels of dopamine. Unknowing psychiatrists frequently misdiagnose these patients and prescribe serotonin enhancing medications which actually exacerbate this type of depression and sometimes make them suicidal.


Deficiencies in certain nutrients can have adverse affects on thyroid function, dopamine & endorphin production, gut toxicity and more.

The majority of thyroid function depends on the conversion of the T4 hormone into the T3 hormone. This process is of conversion is derived from many nutrients and minerals including vitamin D, vitamin B6, magnesium, iron and selenium, etc. When these nutrients are deficient, the T4 to T3 conversion fails to take place


A drop in estradiol levels can adversely affect serotonin levels causing symptoms of depression.

In the female brain, serotonin receptors do not accept serotonin molecules when estradiol levels fall below 60 to 80 pg/dl. This is most common postpartum, post menopause and 4-5 days before menstrual cycle.


Gluteomorphins are opiate-like peptides produced from the improper digestion of gluten which enter the blood stream and disrupt endorphin function.

Gluteomorphins or gliadorphins, are opiate-like peptides produced from the improper digestion of gluten. They enter the blood stream (through a leaky gut) and travel to the brain disrupting normal endorphin function. Depression and anxiety are common in patients with celiac disease.


Dopamine production is reduced when there is less sunshine causing feelings of depression.

Seasonal affective disorder experienced by patients in northern latitudes during the winter months occurs when their exposure to sunshine is markedly decreased. Natural sunshine converts cholesterol in our skin into Vitamin D, which enhances the conversion of tyrosine into dopamine. Therefore, dopamine production is reduced when there is less sunshine.


Heavy metals such as arsenic and mercury can decrease dopamine activity and lead to atypical depression.

Heavy metal exposure may contribute to the development of atypical depression. The heavy metals arsenic and mercury also indirectly decrease dopamine D2 activity because they interfere with the normal function of selenium, a necessary nutrient for conversion of inactive T4 to active T3 thyroid hormone.

Meet the Medical Director of Sponaugle Wellness Institute


With emphasis on Environmental Medicine, Dr. Sponaugle specializes in treating brain and neurological disorders derived from Neurological Lyme disease, Mold Toxicity, Industrial Toxicity, Gut Toxicity, and more. Dr. Sponaugle approaches healing on an intracellular level using biochemistry and detoxification protocols to optimize mitochondrial function.

From his beginnings in the 1980’s practicing Critical Care Medicine and Anesthesiology Dr. Sponaugle felt there was a better way to heal his patients. He began Sponaugle Wellness and has helped thousands of people get better. Dr. Sponaugle has gained national acclaim for his work including being invited to the white house, celebrity collaborations and treatments, publications and numerous television appearances.

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