Biofilm formations – as seen in the before-and-after Blood Smear image* below – serve as a protective shield for Lyme spirochetes, co-infections, parasites and viral infections (like Epstein Barr). The image on left shows Biofilm; the image on right shows no Biofilm.
Neurological Lyme Disease
Dr. Sponaugle has acquired extensive brain expertise from treating thousands of patients with brain and neurological disorders. This greatly enhances his ability to treat Lyme Disease-induced brain dysfunction in neurological Lyme disease patients.
For this reason, Lyme-literate doctors often refer neurological Lyme disease patients to Sponaugle Wellness Institute. Dr. Sponaugle is extremely adept at treating Depression and Anxiety caused by Lyme disease and excessive antibiotic treatment.
Dr. Sponaugle believes that the brain of chronic late-stage Lyme disease patients is always affected by Lyme spirochetes. Many neurological Lyme patients suffer from more severe brain infections. They often suffer from the following symptoms:
- Lyme Partial Complex Seizures
- Unilateral neurological symptoms – such as Bell’s Palsy, facial twitching, one-sided arm or leg weakness, right or left foot drop, unilateral intentional tremors or resting tremors.
How Do Lyme Spirochetes Attack the Brain?
In worldwide MRI studies on patients who tested positive for Borrelia, antibodies in their spinal fluid have proven that spirochetes – which is the corkscrew-shaped bacterium causing Lyme Disease (called Borrelia Burgdorferi) – have a propensity to attack three regions of the brain (which modulate motor function):
- The Sensory Motor Strip
- The Cerebellum
- The Basal Ganglia.
The Basal Ganglia includes the three motor regions that control involuntary movement:
- The Caudate Nucleus
- The Lentiform Nucleus
- The Substantia Nigra (known as the Parkinson’s region).
Dr. Sponaugle uses PET-brain imaging to obtain more sophisticated data of these regions for treatment. Additionally, his PET-scan database now catalogs hundreds of Lyme Disease patients, allowing him to continuously improve treatment for the benefit of others.
Through computerized calculation, PET scans provide numbers for more objective evaluation of brain activity. The PET-scan computer calculates glucose metabolism by brain region, and glucose metabolism correlates with electrical activity.
Dr. Sponaugle’s preference for Lyme Disease Treatment is to reduce the brain’s toxin load to ground zero, before commencing to kill protocols in Neurological Lyme Disease patients.
However, because effective killing of Lyme spirochetes, Bartonella, Protomyxzoa and other infectious organisms releases lipopolysaccharide (LPS) toxins from their cell walls, the brain becomes temporarily more toxic during treatment.
Dr. Sponaugle addresses this as part of treatment by clearing this toxic effect during brain-scans, making it easier to evaluate and treat the brain regions that are under-active due to infection.
Chronic Lyme Disease and Co-Infections
Many patients suffer chronic infections because their toxin-induced immune system isn’t strong enough to destroy Biofilm(see next section for overview). When Dr. Sponaugle uses integrative medicine protocols to restore immune function in Chronic Lyme Disease patients, their immune system properly attacks and destroys Biofilm formations in the bloodstream. Patients will then test positive for multiple undiagnosed Bacterial, Parasitic and Viral infections that were previously hidden in Biofilm*.
Infectious organisms are then released to the free floating-bloodstream. Most commonly diagnosed, in addition to Borrelia Burgdorferi (typically the cause of Lyme Disease), are the following:
- Borrelia Miyamotoi (CA patients)
- Chlamydia Pneumoniae
- Chaga’s Disease (which has moved North in the U.S., and is under-diagnosed in many immunosuppressed Americans)
- Mycoplasma Pneumoniae
- Protomyxzoa Rheumatica
- Rocky Mountain Spotted Fever
- West Nile Virus
What is Biofilm?
Biofilm is a protective shield manufactured by invading organisms to escape attack from our antibodies and natural killer cells (immune system). Biofilm consists of a polysaccharide extracellular matrix described by microbiologists as a “super glue-like” substance.
Lyme spirochetes, Bartonella, and the mosquito parasite, Protomyxzoa Rheumatica, will wrap themselves in Biofilm if they are not immediately destroyed upon entry into our bloodstream. Thinking in three-dimensional terms, visualize Biofilm “bubbles” floating among red blood cells throughout the bloodstream, as seen in this blood smear (upper-left).
Lyme Disease Treatment Causing Gut Toxicity
We have correlated abnormal brain chemistry patterns with Lyme bio-marker CD 57 levels and the abnormalities seen on the brain scans of our Lyme patients. Our Chronic Lyme disease research has proven that antibiotic-induced changes in brain chemistry cause excessive electrical activity in two specific brain regions (as seen in red in the brain scan below).
When these brain regions become severely overactive, patients develop depression and a “worry-worry” type of anxiety. When Chronic Lyme disease patients develop an overactive deep limbic center, they suffer with depression, moodiness, negativity, irritability, hopelessness, excessive guilt, social anxiety, and they become more easily offended. When Chronic Lyme Disease patients develop an overactive anterior cingulate, they become more argumentative, more stubborn, hyper focused on the negative, and they develop obsessive-compulsive worry*.
Antibiotic-Induced Gut Toxicity Suppresses Immune Function
Chronic Lyme disease patients often become more debilitated after months of aggressive antibiotic therapy. Furthermore, prolonged antibiotic therapy suppresses the immune system in Chronic Lyme disease patients. Lyme disease treatment consisting solely of antibiotic therapy can ultimately destroy the intestinal lining (where 70 percent of our immune system is located). Intestinal dysbiosis is the term used to describe an imbalance of intestinal organisms.
Prolonged antibiotic therapy ultimately kills our good intestinal bacteria. Lactobacillus is a healthy intestinal bacterium that produces lactic acid. Lactobacillis thereby ensures that the ph of our intestine remains more acidic disallowing overgrowth of foreign invaders. After prolonged antibiotic therapy, the intestinal ph becomes more alkaline allowing excessive overgrowth of pathogenic yeast and the following toxic bacterium: Klebsiella, Proteus, and Enterobacteriaceae. When Candida mycotoxins and bacterial endotoxins destroy the intestinal lining they also destroy our antibody factory, the Peyer’s patch which is located in our intestinal lining.
Destruction of the intestinal lining also causes severe malnutrition. Several of the essential amino acids are utilized to make natural killer cells. Thus production of killer lymphocytes suffers from a malnourished state. With enough antibiotic-induced destruction of the intestinal lining, Chronic Lyme disease patients develop severe Leaky Gut Syndrome. Once Lyme patients develop significant Leaky Gut Syndrome, their Immune System will waste resources attacking undigested food particles that “leak” across the damaged intestinal lining into the blood stream. Normally, these food particles are too large to cross over from the gut into the bloodstream.
Antibiotic-Induced Gut Toxicity Causes Increased Brain Toxicity
After Chronic Lyme disease patients develop antibiotic-induced gut toxicity, yeast mycotoxins and bacterial endotoxins migrate from the gut to the brain. These toxins are fatty in structure and deposit in the fattiest organ, our brain which is 60 percent fat. These neurotoxins inflame the brain’s white matter, the insulation on brain neurons called myelin, adding to the cumulative level of neurotoxicity which is already significant from an accumulation of Lyme toxins in Lyme patients. Antibiotic-induced neurotoxicity causes further suppression of the immune system by “shutting down” the electrical current in the brain. This is problematic, because the brain’s electrical activity is responsible for stimulating cytokine activity. Cytokines are the chemical messengers that activate our natural killer cells. When neurotoxins inflame the myelin sheath of brain neurons, they change the electromagnetic field surrounding the neuron; slowing the speed of the electrical impulse. By this mechanism, neurotoxins essentially suppress the brain’s electrical activity. In a healthy brain, electrical current jumps over the myelin on brain neurons in rapid fashion. However, when the myelin sheath becomes infiltrated with fatty neurotoxins from the gut, in addition to toxins from the Lyme disease spirochete, it fails to effectively modulate immune function.