Why Use the NutrEval FMV Profile?
The NutrEval profile is the most comprehensive functional and nutritional assessment available. It is designed to help practitioners identify root causes of dysfunction and treat clinical imbalances that are inhibiting optimal health. This advanced diagnostic tool provides a systems-based approach for clinicians to help their patients overcome chronic conditions and live a healthier life.
The NutrEval assesses a broad array of macronutrients and micronutrients, as well as markers that give insight into digestive function, toxic exposure, mitochondrial function, and oxidative stress. It accomplishes this by evaluating organic acids, amino acids, fatty acids, oxidative stress markers, and nutrient & toxic elements.
Subpanels of the NutrEval are also available as stand-alone options for a more focused assessment. The NutrEval offers a user-friendly report with clinically actionable results, including:
- Nutrient recommendations for key vitamins, minerals, amino acids, fatty acids, and digestive support are based on a functional evaluation of important biomarkers.
- Functional pillars with a built-in scoring system to guide therapy around needs for methylation support, toxic exposures, mitochondrial dysfunction, fatty acid imbalances, and oxidative stress.
- Interpretation-At-A-Glance pages provide educational information on nutrient function, causes and complications of deficiencies, and dietary sources.
- Dynamic biochemical pathway charts provide a clear understanding of how specific biomarkers play a role in biochemistry.
There are various methods of assessing nutrient status, including intracellular, extracellular, direct, and functional measurements. Each method has certain strengths and weaknesses.
The NutrEval uses a combination of all these methods and synthesizes the information via an algorithm that determines personalized nutrient needs. The algorithm is based on functional markers shown in the literature to be associated with a need for that particular nutrient.
When should testing for NutrEval FMV be considered?
According to the World Health Organization, every country in the world is affected by one or more forms of malnutrition. The term malnutrition addresses 3 broad groups of conditions:1
- Undernutrition (wasting, stunting, underweight)
- Micronutrient-related malnutrition from inadequate or excess vitamins or minerals
- Overweight, obesity, and diet-related noncommunicable diseases (such as heart disease, stroke, diabetes, and some cancers)
Proper nutrition is key to preventing several diseases. Nutrients are necessary to feed every cell and ensure all body systems function properly. Testing can help clinicians and patients gain an understanding of how nutritional imbalances may be impacting their health.
Certain conditions or dietary, genetic, and lifestyle factors may predispose a person to having nutrient imbalances.
What is a functional nutritional assessment?
A functional nutrition assessment looks at metabolic intermediates produced in enzymatic pathways of cellular energy production, detoxification, neurotransmitter breakdown, and amino acid metabolism.
Elevated metabolite levels may signal a metabolic inhibition or block. This abnormality may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
An individual can have normal blood levels of vitamins to maintain homeostasis while exhibiting signs of insufficiency/ deficiency for that vitamin.
For this reason, direct testing of individual nutrients alone does not provide a complete picture.
What is included on the NutrEval profile?
- Organic Acids provide insight into key metabolic irregularities that relate to potential nutritional cofactor needs, digestive irregularities, cellular energy production, neurotransmitter metabolism, and detoxification.
- Oxidative Stress markers indicate problems in two key areas: antioxidant capacity and oxidative damage. Oxidative stress is relevant to an entire host of clinical conditions. It reflects a need to support antioxidant intervention along with the reduction of free radical exposure.
- Amino Acids are important in many different clinical conditions. The NutrEval looks at essential and nonessential amino acids as well as markers that may indicate poor digestion, absorption, or metabolism of the amino acids.
- Fatty Acids reflect the intake and metabolism of essential fatty acids, which are relevant to many processes, including inflammatory balance, cell membrane fluidity, and cell signaling, among others. This assessment helps clinicians to determine appropriate nutritional interventions to correct EMFA imbalances.
- Nutrients & Toxic Elements provide a window into short-term exposure to various toxins such as mercury, lead, cadmium, and arsenic. Also included are direct evaluations of key minerals such as magnesium, potassium, zinc, copper, and selenium to further determine nutritional adequacy.
What is a functional nutritional assessment?
A functional nutrition assessment looks at metabolic intermediates produced in enzymatic pathways of cellular energy production, detoxification, neurotransmitter breakdown, and amino acid metabolism.
Elevated metabolite levels may signal a metabolic inhibition or block. This abnormality may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
An individual can have normal blood levels of vitamins to maintain homeostasis while exhibiting signs of insufficiency/ deficiency for that vitamin.
For this reason, direct testing of individual nutrients alone does not provide a complete picture.
What is included on the NutrEval profile?
- Organic Acids provide insight into key metabolic irregularities that relate to potential nutritional cofactor needs, digestive irregularities, cellular energy production, neurotransmitter metabolism, and detoxification.
- Oxidative Stress markers indicate problems in two key areas: antioxidant capacity and oxidative damage. Oxidative stress is relevant to an entire host of clinical conditions. It reflects a need to support antioxidant intervention along with the reduction of free radical exposure.
- Amino Acids are important in many different clinical conditions. The NutrEval looks at essential and nonessential amino acids as well as markers that may indicate poor digestion, absorption, or metabolism of the amino acids.
- Fatty Acids reflect the intake and metabolism of essential fatty acids, which are relevant to many processes, including inflammatory balance, cell membrane fluidity, and cell signaling, among others. This assessment helps clinicians to determine appropriate nutritional interventions to correct EMFA imbalances.
- Nutrients & Toxic Elements provide a window into short-term exposure to various toxins such as mercury, lead, cadmium, and arsenic. Also included are direct evaluations of key minerals such as magnesium, potassium, zinc, copper, and selenium to further determine nutritional adequacy.
What advantage does the NutrEval FMV offer compared to other diagnostics?
The NutrEval FMV is one of the most comprehensive nutritional profiles available, assessing a broad array of macronutrients and micronutrients, as well as markers that give insight into digestive function, toxic exposure, mitochondrial function, and oxidative stress.
Genova provides a user-friendly report with clinically actionable results, including:
- Suggested digestive support and vitamin, mineral, amino acid, and fatty acid recommendations based on an algorithmic calculation of the functional need for cofactors in the body's metabolism
- Functional pillars with a built-in scoring system to guide therapy for methylation support, toxic exposures, mitochondrial dysfunction, fatty acid imbalances, and oxidative stress
- Interpretation-At-A-Glance pages provide educational information on nutrient function, causes and complications of deficiencies, and dietary sources.
A Functional Nutritional Assessment
There are various methods of assessing nutrient status, including intracellular and extracellular direct measurement and measuring biochemical pathway markers that require specific nutrient cofactors for proper metabolism.
The NutrEval combines these methods and synthesizes the information via an algorithm that determines personalized nutrient needs. The algorithm is based on functional markers shown in the literature to be associated with a need for a particular nutrient.
Functional evaluation of nutritional status assesses metabolic intermediates produced in enzymatic pathways of cellular energy production, detoxification, neurotransmitter breakdown, and amino acid metabolism.
Specific metabolites outside the reference range may signal a metabolic inhibition or block. This abnormality may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
An individual can have normal blood levels of vitamin to maintain homeostasis while exhibiting signs of insufficiency/deficiency for that vitamin. For this reason, direct testing of individual nutrients alone does not provide a complete picture.
Other methods of assessing nutrient status, such as intracellular lymphocyte testing, have limited literature support.
Conventional nutritional panels include tests such as complete blood count, comprehensive metabolic panel, iron, ferritin, and other select nutrients. The NutrEval is not meant to substitute for this important testing but rather a complement by providing additional information.