IV Proline

Proline (aka L-proline) is an amino acid, an organic molecule that creates protein.

Benefits of Proline in IV Therapy

Proline (aka L-proline) is an amino acid, an organic molecule that creates protein. Proline is synthesized in the body and also obtained through foods you eat.

Proline is unique in the twenty amino acids because its molecular structure differs. Proline’s unique configuration allows it to fold in specific ways to form proteins like collagen, making it especially important for healing and maintaining the health of skin and connective tissues.

Proline health benefits

Proline is essential for protein synthesis and structure, metabolism, wound healing, and immune response.1 L-proline also supports digestive and cardiovascular health.

L-proline skin benefits

Collagen is a crucial part of skin tissue, and skin with high collagen levels appears more youthful, firm, and elastic. Proline not only boosts collagen production, it also protects against collagen loss, which helps improve skin’s texture and appearance.

Your body ramps proline synthesis for wound healing and repair of other soft-tissue injuries (even muscle recovery). Sufficient proline levels are critical for healing the skin and other soft tissues.2 IV infusion is the fastest way to send proline and other beneficial nutrients straight to your bloodstream for complete absorption.

Proline and digestion

Because proline is so crucial for collagen synthesis, it directly impacts the tissues of your digestive tract. This can help remedy leaky gut syndrome, reducing autoimmune disorders.3

L-proline and joint health

Collagen is the main component of connective tissues like the cartilage, tendons, and ligaments making up your joints. From about age 35 onwards, our bodies make less collagen. Collagen can also be lost due to stress and unhealthy eating and drinking habits. Because proline is essential for collagen production, ensuring you’re getting plenty of it is one way to increase collagen synthesis, regenerate cartilage and improve joint health.4

Proline and heart health

Collagen is also used to build tissues for blood vessels. Strengthening artery walls is one way to prevent atherosclerosis (obstruction of blood flow caused by plaque buildup in arteries). L-proline is essential because collagen strengthens artery walls to prevent the hardening of the arteries.5

L-proline and your immune system

Gut health is essential for proper immune system function, so proline also supports a healthy immune response by improving the tissues lining the digestive tract.

Protein deficiency suppresses immune function6 and makes you more vulnerable to infection. Maintaining healthy levels of proline and other amino acids ensures protein requirements for the immune system can be more easily met.


  1. Wu, Guoyao et al. “Proline and hydroxyproline metabolism: implications for animal and human nutrition.” Amino acids vol. 40,4 (2011): 1053-63. doi:10.1007/s00726-010-0715-z
  2. Albaugh, Vance L et al. “Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing.” The Journal of Nutrition vol. 147,11 (2017): 2011-2017. doi:10.3945/jn.117.256404
  3. de Paz-Lugo, Patricia, et al. “High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis.” Amino acids vol. 50,10 (2018): 1357-1365. doi:10.1007/s00726-018-2611-x
  4. Wong, Ang-Peng, et al. “The effect of multiple micronutrient supplementation on quality of life in patients with symptomatic heart failure secondary to ischemic heart disease: a prospective case series clinical study.” American Journal of cardiovascular disease vol. 5,3 146-52. 15 Sep. 2015
  5. Ruth, Megan R, and Catherine J Field. “The immune modifying effects of amino acids on gut-associated lymphoid tissue.” Journal of animal science and Biotechnology vol. 4,1 27. 30 Jul. 2013, doi:10.1186/2049-1891-4-27
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